Price locks can be used to lock prices and stop automatic recalculation on products that use a percentage base calculation.
To lock a price on an eligible line item, check the line item box at left. Then use the drop down menu in the top right, and click "Toggle Price Locks".
Once completed, the sales price and discounts will be blanked out and you will no longer be able to change the price until it is unlocked. There will also be a toggle icon displayed in the Sales Price column letting you know the price is locked.
To unlock the price lock, simple follow the same process, and the product will return back to normal.
To Enable Price Locks:
As an Admin, browse to the User Preferences and set "Lock Percentage Prices".